E7-IHC (E7 Immunohistochemistry)

Background Information：

Oncogene E6/E7 encoded by the high-risk HPV genome can only express their gene products, E6 and E7 oncoprotein after the integration of viral genes into the host (human) genome. Indepth studies and vast research reports have established the oncogenic roles of E6 and E7 protein, and their molecular and cellular mechanisms in tumorigenesis of HPV transformed human host cells. E7 protein plays a key role in disrupting the signal pathway of cell cycle, leading to the transformation and tumorigenesis of cervical epithelial cells. Therefore, E6 and E7 protein represent an ideal choice of molecular target for therapeutics and for cancer diagnosis.

E7 antibody reagent (E7-IHC) for immunohistochemistry works through the antigen-antibody high affinity and specific binding to achieve the specific identification of cancer cells with biomarker precision. E7 positive cells or tissue exhibit brown staining after antibody treatment. The result can be observed under a pathology microscope. E7 positive staining indicates the cancer stage and status in the tissue. Because of its potent oncogenic role, a strong positive expression of E7 protein in the tissue indicates the active growth status and the aggressiveness of the tumor.